Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.
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ABSTRACT:
SUBMITTER: Chen K
PROVIDER: S-EPMC6828159 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.
Chen Ka K Liu Hongliang H Liu Zhensheng Z Luo Sheng S Patz Edward F EF Moorman Patricia G PG Su Li L Shen Sipeng S Christiani David C DC Wei Qingyi Q
International journal of cancer 20190201 3
Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine-metabolic genes are associated with survival in nonsmall cell lung cancer (NSCLC) patients. Therefore, we investigated associations of 16,378 common single-nucleotide polymorphisms (SNPs) in 97 methionine-metabolic pathway genes with overall survival (OS) in NSCLC patients using genotyping data from two published genome ...[more]
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