Genomic subtyping and therapeutic targeting of acute erythroleukemia.
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ABSTRACT:
SUBMITTER: Iacobucci I
PROVIDER: S-EPMC6828160 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci Ilaria I Wen Ji J Meggendorfer Manja M Choi John K JK Shi Lei L Pounds Stanley B SB Carmichael Catherine L CL Masih Katherine E KE Morris Sarah M SM Lindsley R Coleman RC Janke Laura J LJ Alexander Thomas B TB Song Guangchun G Qu Chunxu C Li Yongjin Y Payne-Turner Debbie D Tomizawa Daisuke D Kiyokawa Nobutaka N Valentine Marcus M Valentine Virginia V Basso Giuseppe G Locatelli Franco F Enemark Eric J EJ Kham Shirley K Y SKY Yeoh Allen E J AEJ Ma Xiaotu X Zhou Xin X Sioson Edgar E Rusch Michael M Ries Rhonda E RE Stieglitz Elliot E Hunger Stephen P SP Wei Andrew H AH To L Bik LB Lewis Ian D ID D'Andrea Richard J RJ Kile Benjamin T BT Brown Anna L AL Scott Hamish S HS Hahn Christopher N CN Marlton Paula P Pei Deqing D Cheng Cheng C Loh Mignon L ML Ebert Benjamin L BL Meshinchi Soheil S Haferlach Torsten T Mullighan Charles G CG
Nature genetics 20190329 4
Acute erythroid leukemia (AEL) is a high-risk leukemia of poorly understood genetic basis, with controversy regarding diagnosis in the spectrum of myelodysplasia and myeloid leukemia. We compared genomic features of 159 childhood and adult AEL cases with non-AEL myeloid disorders and defined five age-related subgroups with distinct transcriptional profiles: adult, TP53 mutated; NPM1 mutated; KMT2A mutated/rearranged; adult, DDX41 mutated; and pediatric, NUP98 rearranged. Genomic features influen ...[more]
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