Optoacoustic imaging of the breast: correlation with histopathology and histopathologic biomarkers.

ABSTRACT:

Aim

This study was conducted in order to investigate the role of gray-scale ultrasound (US) and optoacoustic imaging combined with gray-scale ultrasound (OA/US) to better differentiate between breast cancer molecular subtypes.

Materials and methods

All 67 malignant masses included in the Maestro trial were retrospectively reviewed to compare US and OA/US feature scores and histopathological findings. Kruskal-Wallis tests were used to analyze the relationship between US and OA/US features and molecular subtypes of breast cancer. If a significant relationship was found, additional Wilcoxon-Mann-Whitney tests were used to identify the differences between molecular subtype groups.

Results

US sound transmission helped to differentiate between LUMA and LUMB, LUMB and TNBC,

SUBMITTER: Menezes GLG 

PROVIDER: S-EPMC6828639 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature