Ontology highlight
ABSTRACT:
SUBMITTER: Nozeret K
PROVIDER: S-EPMC6828757 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Nozeret Karine K Boucharlat Alix A Agou Fabrice F Buddelmeijer Nienke N
Scientific reports 20191104 1
Lipoprotein modification is an essential process in Gram-negative bacteria. The action of three integral membrane proteins that catalyze the transfer of fatty acids derived from membrane phospholipids or cleave the signal peptide of the lipoprotein substrate result in the formation of mature triacylated proteins. Inactivation of the enzymes leads to mis-localization of immature lipoproteins and consequently cell death. Biochemical studies and the development of in vitro assays are challenging du ...[more]