Effect of population stratification on SNP-by-environment interaction.

ABSTRACT: Proportions of false-positive rates in genome-wide association analysis are affected by population stratification, and if it is not correctly adjusted, the statistical analysis can produce the large false-negative finding. Therefore various approaches have been proposed to adjust such problems in genome-wide association studies. However, in spite of its importance, a few studies have been conducted in genome-wide single nucleotide polymorphism (SNP)-by-environment interaction studies. In this report, we illustrate in which scenarios can lead to the false-positive rates in association mapping and approach to maintaining the overall type-1 error rate.

SUBMITTER: An J 

PROVIDER: S-EPMC6829023 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature