Dataset Information

Global vs. Network-Specific Regulations as the Source of Intrinsic Coactivations in Resting-State Networks.

ABSTRACT: Spontaneous neural activities are endowed with specific patterning characterized by synchronizations within functionally relevant distant regions that are termed as resting-state networks (RSNs). Although the mechanisms that organize the large-scale neural systems are still largely unknown, recent studies have proposed a hypothesis that network-specific coactivations indeed emerge as the result of globally propagating neural activities with specific paths of transmission. However, the extent to which such a centralized global regulation, rather than network-specific control, contributes to the RSN synchronization remains unknown. In the present study, we investigated the contribution from each mechanism by directly identifying the global as well as local component of resting-state functional MRI (fMRI) data provided by human connectome project, using temporal independent component analysis (ICA). Based on the spatial distribution pattern, each ICA component was classified as global or local. Time lag mapping of each IC revealed several paths of global or semi-global propagations that are partially overlapping yet spatially distinct to each other. Consistent with previous studies, the time lag of global oscillation, although being less spatially homogenous than what was assumed to be, contributed to the RSN synchronization. However, an equivalent contribution was also shown on the part of the more locally confined activities that are independent to each other. While allowing the view that network-specific coactivation occurs as part of the sequences of global neural activities, these results further confirm an equally important role of the network-specific regulation for its coactivation, regardless of whether vascular artifacts contaminate the global component in fMRI measures.

SUBMITTER: Amemiya S

PROVIDER: S-EPMC6829116 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Global vs. Network-Specific Regulations as the Source of Intrinsic Coactivations in Resting-State Networks.

Amemiya Shiori S Takao Hidemasa H Abe Osamu O

Frontiers in systems neuroscience 20191029

Spontaneous neural activities are endowed with specific patterning characterized by synchronizations within functionally relevant distant regions that are termed as resting-state networks (RSNs). Although the mechanisms that organize the large-scale neural systems are still largely unknown, recent studies have proposed a hypothesis that network-specific coactivations indeed emerge as the result of globally propagating neural activities with specific paths of transmission. However, the extent to ...[more]

PMID: 31736721

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Project description:We studied with functional magnetic resonance imaging (fMRI) differences in resting-state networks between patients with mesial temporal lobe epilepsy (MTLE) and healthy subjects. To avoid any a priori hypothesis, we use a data-driven analysis assessing differences between groups independently of structures involved. Shared and specific independent component analysis (SSICA) is an exploratory method based on independent component analysis, which performs between-group network comparison. It extracts and classifies components (networks) in those common between groups and those specific to one group. Resting fMRI data were collected from 10 healthy subjects and 10 MTLE patients. SSICA was applied multiple times with altered initializations and different numbers of specific components. This resulted in many components specific to patients and to controls. Spatial clustering identified the reliable resting-state networks among all specific components in each group. For each reliable specific network, power spectrum analysis was performed on reconstructed time-series to estimate connectivity in each group and differences between groups. Two reliable networks, corresponding to statistically significant clusters robustly detected with clustering were labeled as specific to MTLE and one as specific to the control group. The most reliable MTLE network included hippocampus and amygdala bilaterally. The other MTLE network included the postcentral gyri and temporal poles. The control-specific network included bilateral precuneus, anterior cingulate, thalamus, and parahippocampal gyrus. Results indicated that the two MTLE networks show increased connectivity in patients, whereas the control-specific network shows decreased connectivity in patients. Our findings complement results from seed-based connectivity analysis (1). The pattern of changes in connectivity between mesial temporal lobe structures and other areas may help us understand the cognitive impairments often reported in patients with MTLE.

Project description:Advancing age is commonly associated with changes in both brain structure and function. Recently, the suggestion that alterations in brain connectivity may drive disruption in cognitive abilities with age has been investigated. However, the interaction between the effects of age and gender on the re-organization of resting-state networks is not fully understood. This study sought to investigate the effect of both age and gender on intra- and inter-network functional connectivity (FC) and the extent to which resting-state network (RSN) node definition may alter with older age. We obtained resting-state functional magnetic resonance images from younger (n = 20) and older (n = 20) adults and assessed the FC of three main cortical networks: default mode (DMN), dorsal attention (DAN), and saliency (SN). Older adults exhibited reduced DMN intra-network FC and increased inter-network FC between the anterior cingulate cortex (ACC) and nodes of the DAN, in comparison to younger participants. Furthermore, this increase in ACC-DAN inter-network FC with age was driven largely by male participants. However, further analyses suggested that the spatial location of ACC, bilateral anterior insula and orbitofrontal cortex RSN nodes changed with older age and that age-related gender differences in FC may reflect spatial re-organization rather than increases or decreases in FC strength alone. These differences in both the FC and spatial distribution of RSNs between younger and older adults provide evidence of re-organization of fundamental brain networks with age, which is modulated by gender. These results highlight the need to further investigate changes in both intra- and inter-network FC with age, whilst also exploring the modifying effect of gender. They also emphasize the difficulties in directly comparing the FC of RSN nodes between groups and suggest that caution should be taken when using the same RSN node definitions for different age or patient groups to investigate FC.

Dataset Information

Global vs. Network-Specific Regulations as the Source of Intrinsic Coactivations in Resting-State Networks.

Publications

Global vs. Network-Specific Regulations as the Source of Intrinsic Coactivations in Resting-State Networks.

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