Ontology highlight
ABSTRACT:
SUBMITTER: Dong Y
PROVIDER: S-EPMC6829146 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Dong Yan Y Li Haimei H Zhao Liang L Koopman Peter P Zhang Feng F Huang Johnny X JX
G3 (Bethesda, Md.) 20191105 11
The emergence of the CRISPR-Cas9 system has triggered a technical revolution in mammalian genome editing. Compared to traditional gene-targeting strategies, CRISPR-Cas9 technology offers a more efficient and cost-effective approach for generating genetically modified animal models. However, off-target cleavage in CRISPR-mediated genome editing is a major concern in the analysis of phenotypes as well as the selection of therapeutic targets. Here, we analyzed whole-genome sequencing (WGS) data fro ...[more]