A Systematic Review of Interpathologist Agreement in Histologic Classification of Lupus Nephritis.

ABSTRACT:

Introduction

Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), resulting in increased morbidity and mortality. The gold standard for diagnosis of LN is a renal biopsy. Considering the importance of the biopsy in determining long-term prognostication and treatment decisions, it is crucial to assess renal histopathology with utmost accuracy and precision. This review represents a systematic search of published literature to estimate the degree of interpathologist reproducibility in current assessment of LN.

Methods

Using the PubMed and Google Scholar search engines, studies analyzing the agreement of 4 or more pathologists assessing LN slides using the ISN/Renal Pathology Society (RPS) classification, activity index, and chron

SUBMITTER: Dasari S 

PROVIDER: S-EPMC6829183 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature