TNF-α Production by Monocytes Stimulated With Epstein-Barr Virus-Peptides as a Marker of Immunosuppression-Related Adverse Events in Kidney Transplant Recipients.

ABSTRACT:

Introduction

Infections and cancers now outnumber rejection as a cause of morbidity in transplant recipients, likely as a result of over-immunosuppression. Currently, there is no clinical tool to detect over-immunosuppression. We recently reported that tumor necrosis factor alpha (TNF-α) production by CD14⁺CD16⁺ intermediate monocytes, following ex vivo stimulation by Epstein-Barr virus-peptides, could identify over-immunosuppressed patients.

Methods

We conducted a pilot study the assay using 142 peripheral blood mononuclear samples from a cohort of 71 kidney transplant recipients. Patients were classified as cases or controls according to the occurrence of opportunistic infection, recurring bacterial infections or de novo neoplasia in the

SUBMITTER: Bouchard-Boivin F 

PROVIDER: S-EPMC6829185 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature