Serotonin transport in the 21st century.
Ontology highlight
ABSTRACT:
SUBMITTER: Rudnick G
PROVIDER: S-EPMC6829555 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Serotonin transport in the 21st century.
Rudnick Gary G Sandtner Walter W
The Journal of general physiology 20190930 11
Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. SERT is the target for many antidepressant medications as well as psychostimulants such as cocaine and ecstasy (3,4-methylenedioxymethamphetamine). SERT belongs to the SLC6 family of ion-coupled transporters and is structurally related to several other transporter families. SERT ...[more]
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