Ontology highlight
ABSTRACT:
SUBMITTER: Sullivan DP
PROVIDER: S-EPMC6829592 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Sullivan David P DP Dalal Prarthana J PJ Jaulin Fanny F Sacks David B DB Kreitzer Geri G Muller William A WA
The Journal of experimental medicine 20190808 11
Transendothelial migration (TEM) of leukocytes across the endothelium is critical for inflammation. In the endothelium, TEM requires the coordination of membrane movements and cytoskeletal interactions, including, prominently, recruitment of the lateral border recycling compartment (LBRC). The scaffold protein IQGAP1 was recently identified in a screen for LBRC-interacting proteins. Knockdown of endothelial IQGAP1 disrupted the directed movement of the LBRC and substantially reduced leukocyte TE ...[more]