Ontology highlight
ABSTRACT:
SUBMITTER: Orning P
PROVIDER: S-EPMC6829603 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Orning Pontus P Lien Egil E Fitzgerald Katherine A KA
The Journal of experimental medicine 20190923 11
The gasdermins are a family of pore-forming proteins recently implicated in the immune response. One of these proteins, gasdermin D (GSDMD), has been identified as the executioner of pyroptosis, an inflammatory form of lytic cell death that is induced upon formation of caspase-1-activating inflammasomes. The related proteins GSDME and GSDMA have also been implicated in autoimmune diseases and certain cancers. Most gasdermin proteins are believed to have pore-forming capabilities. The best-studie ...[more]