Dataset Information

Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study.

ABSTRACT:

Objectives

Lifestyle may affect observed associations between glucocorticoid use and adverse events. This study aimed to investigate whether lifestyle differ according to use of systemic glucocorticoids.

Design

Population-based cross-sectional study.

Setting

The Central Denmark Region.

Participants

30?245 adults (?25 years of age) who participated in a questionnaire-based public health survey in 2010.

Outcome measures

Systemic glucocorticoid use was categorised as never use, current use (prescription redemption ?90 days before completing the questionnaire), recent use (prescription redemption 91-365 days before completing the questionnaire), former use (prescription redemption >365 days before completing the questionnaire) and according to cumulative dose expressed in prednisolone equivalents (<100, 100-499, 500-999, 1000-1999, 2000-4999, ?5000?mg). We computed the prevalence of lifestyle factors (body mass index, smoking, alcohol intake, physical activity and dietary habits) according to glucocorticoid use. We then estimated age-adjusted prevalence ratios (aPRs) and 95% CIs, comparing the categories of glucocorticoid users versus never users. All analyses were stratified by sex.

Results

Of the 30?245 participants (53% women, median age 53 years), 563 (1.9%) were current users, 885 (2.9%) were recent users, 3054 (10%) were former users and 25?743 (85%) were never users. Ever users of glucocorticoids had a slightly higher prevalence of obesity than never users (18% vs 14%, aPR=1.4, 95%?CI 1.2 to 1.5 in women and 17% vs 15%, aPR=1.2, 95%?CI 1.1 to 1.4 in men). In women, ever users of glucocorticoids had a slightly lower prevalence of high-risk alcohol consumption compared with never users (17% vs 20%, aPR=0.8, 95%?CI 0.7 to 1.0). Smoking, diet and physical activity did not differ substantially according to use of glucocorticoids.

Conclusion

Our study provides a framework for quantifying potential uncontrolled confounding by lifestyle factors in studies of systemic glucocorticoids.

SUBMITTER: Laugesen K

PROVIDER: S-EPMC6830647 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study.

Laugesen Kristina K Petersen Irene I Pedersen Lars L Breinholt Larsen Finn F Jørgensen Jens Otto Lunde JOL Sørensen Henrik Toft HT

BMJ open 20191028 10

<h4>Objectives</h4>Lifestyle may affect observed associations between glucocorticoid use and adverse events. This study aimed to investigate whether lifestyle differ according to use of systemic glucocorticoids.<h4>Design</h4>Population-based cross-sectional study.<h4>Setting</h4>The Central Denmark Region.<h4>Participants</h4>30 245 adults (≥25 years of age) who participated in a questionnaire-based public health survey in 2010.<h4>Outcome measures</h4>Systemic glucocorticoid use was categorise ...[more]

PMID: 31662378

Similar Datasets

Project description:BackgroundRisky sexual behaviors adversely affect the health of youth and young adults exposing them to sexually transmitted infections including HIV/AIDS and unwanted pregnancy to females that in turn lead to deleterious health, social and economic consequences. Youth centers inform their clients on sexually transmitted diseases, including HIV/AIDS, unwanted pregnancy, high risk abortion, and other reproductive health problems. Therefore, this study was designed to assess the prevalence of risky sexual behaviors among youth center reproductive health clinic users and non-users in Addis Ababa.MethodsA comparative cross-sectional study design was carried out among 524 youth in Addis Ababa from March to April, 2016. The data was entered in EPI-INFO 7 software; and cleaned and analyzed using SPSS version 16.0. The prevalence was computed. Binary and multivariable logistic regression was done to determine the strength, direction and significance of association between youth center reproductive health clinic utilization and risky sexual behavior and to control confounder variables respectively.ResultsA total of 524 youth with the response rate of 92% participated in the study. The overall prevalence of risky sexual behavior was 226 (43.1%) (With statistically significant difference in prevalence among users 101 (38.5%) and non-users 125 (47.7%) of youth center clinics, (p-value = 0.04). The odds of reporting risky sexual behavior was 60% higher among volunteers who did not use the reproductive health clinic, relative to those who did (AOR = 1.60; 95%CI = 1.08, 2.37). Teenagers aged 15-19 years were (AOR = 0.08; 95%CI = 0.05, 0.15) 92% less likely to practice risky sexual behavior compared to those aged 25-29 years old.ConclusionRisky sexual behavior was statistically significantly higher among non-users of the youth center reproductive health clinic compared with the users. In addition, a substantial proportion of the youth engaged in different risky sexual behaviors that are evidenced by the existence of multiple sexual partners, sexual practice without condom and early sexual debut that might predispose youth to STIs including HIV infection and unwanted pregnancy. The ministry of health and its partners should strengthen youth center reproductive health clinics in urban, semi-urban and rural parts of Ethiopia.

Project description:BackgroundIn addition to the aging process, risk factors for hearing loss in adults include, among others, exposure to noise, use of ototoxic drugs, genetics, and limited access to medical care. Differences in exposure to these factors are bound to be reflected in the prevalence of hearing loss. Assessment of hearing loss can easily be carried out on a large scale and at low cost using mobile apps.ObjectiveThis study aimed to conduct a worldwide assessment of the differences in hearing loss prevalence between countries in a group of mobile device users.MethodsHearing tests were conducted using the open-access Android-based mobile app Hearing Test. The app is available free of charge in the Google Play store, provided that consent to the use of the results for scientific purposes is given. This study included hearing tests carried out on device models supported by the app with bundled headphones in the set. Calibration factors for supported models were determined using the biological method. The tests consisted of self-determining the quietest audible tone in the frequency range from 250 Hz to 8 kHz by adjusting its intensity using the buttons. The ambient noise level was optionally monitored using a built-in microphone. Following the test, the user could compare his hearing threshold against age norms by providing his or her age. The user's location was identified based on the phone's IP address.ResultsFrom November 23, 2016 to November 22, 2019, 733,716 hearing tests were conducted on 236,716 mobile devices across 212 countries. After rejecting the tests that were incomplete, performed with disconnected headphones, not meeting the time criterion, repeated by the same user, or carried out regularly on one device, 116,733 of 733,716 tests (15.9%) were qualified for further analysis. The prevalence of hearing loss, defined as the average threshold at frequencies 0.5 kHz, 1 kHz, 2 kHz, and 4 kHz above 25 dB HL in the better ear, was calculated at 15.6% (95% CI 15.4-15.8). Statistically significant differences were found between countries (P<.001), with the highest prevalences for Bangladesh, Pakistan, and India (>28%) and the lowest prevalences for Taiwan, Finland, and South Korea (<11%).ConclusionsHearing thresholds measured by means of mobile devices were congruent with the literature data on worldwide hearing loss prevalence. Uniform recruitment criteria simplify the comparison of the hearing loss prevalence across countries. Hearing testing on mobile devices may be a valid tool in epidemiological studies carried out on a large scale.

Project description:OBJECTIVES:Population-based studies on use of non-obstetric and obstetric surgical procedures during pregnancy are sparse. Therefore, our objective was to estimate the prevalence of surgery during pregnancy, including potential time trends, overall and by trimester and describe the characteristics of pregnant women undergoing surgery. DESIGN:This study is a large nationwide cohort study. SETTING:From administrative and medical databases, we obtained information about all pregnancies ending in a live birth, a stillbirth or an abortion (spontaneous and induced) in Denmark during 1996-2015. Procedures (excluding caesarean sections) conducted during pregnancy were categorised as a non-obstetric or obstetric surgery and further divided into laparoscopic or non-laparoscopic procedures. MAIN OUTCOME MEASURE:Main outcome measure is prevalence of surgery during pregnancy. RESULTS:We included 1 687 176 pregnancies of which 108 502 (6.4%) received 117 424 surgical procedures. The prevalence of non-obstetric surgery was almost stable (1.5% in 1996-1999 to 1.6% in 2012-2015), whereas non-obstetric abdominal or gynaecological laparoscopic procedures increased from 0.5% to 0.8%. For appendectomies, the proportion of laparoscopic surgery increased from 4.2% to 79.2% during the study period. In 49 pregnancies, surgery for internal herniation was conducted in 2012-2015 versus none in 1996-1999. The prevalence of obstetric surgery, excluding invasive diagnostic tests, increased from 0.2% to 0.8%. High multiplicity, smoking, increasing age, body mass index (BMI) and parity were factors associated with a high prevalence of surgery during pregnancy. CONCLUSIONS:The increase in the prevalence of laparoscopic surgery during pregnancy may reflect a decreased restraint concerning conductance of these surgical procedures during pregnancy. The increasing proportion of laparoscopic procedures complies with clinical recommendations, and the prevalence of surgery during pregnancy varied by multiplicity, smoking status, parity, age and BMI.

Project description:Emotional eating seems to emerge during the transition from childhood to adulthood; however, limited research has explored the association between emotional overeating and quality of life (QoL) in children with overweight and obesity. Therefore, the aim of this study was to examine the association between QoL and emotional overeating in a Danish sample of children with overweight and obesity. The present cross-sectional study is based on baseline questionnaire data from a nonrandomized controlled trial. Children attending a 10-week multicomponent lifestyle camp from October 2020 to March 2022 was invited to participate. Multiple linear regressions were used to examine if QoL was associated with emotional overeating before starting camp. In total, 229 children were included, and 45 children were excluded due to missing data, leaving 184 children in this study. The children had a mean age of 11.8 years (SD ± 1.38), with 60.9% girls and 39.1% boys, and the majority (94.6%) had overweight or obesity defined by a Body Mass Index Standard Deviation Score (BMI-SDS) > 1 SD. On average, children with a high tendency of emotional overeating had a 13.7 (95% CI 18.9; 8.5, p < 0.01) lower QoL score compared to children with a low tendency of emotional overeating. Conclusions: This study shows that children with a high tendency of emotional overeating have lower quality of life, compared to children with a lower tendency of emotional overeating. Due to study limitations, the findings should be supported by further research. (Trial registration: clinicaltrials.gov with ID: NCT04522921). What is Known: • Emotional eating seems to emerge during the transition from childhood to adulthood. • Limited research has explored the association between quality of life and emotional overeating in children with overweight and obesity. What is New: • Children with a high tendency of emotional overeating had a lower quality of life compared to children with a lower tendency of emotional overeating. • Emotional overeating was negatively associated with quality of life in children with overweight and obesity.

Dataset Information

Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study.

Objectives

Design

Setting

Participants

Outcome measures

Results

Conclusion

Publications

Prevalence of lifestyle characteristics in glucocorticoid users and non-users: a Danish population-based cross-sectional study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets