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Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment.


ABSTRACT: Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) - the latter most resembling inflammatory bowel disease in people. The aim of this study was to characterize duodenal macrophages (M?) in CE using immunohistochemistry; with calprotectin (CAL) as a marker of early differentiated M? and CD163 expression as a marker for resident M? in the duodenum before and after treatment. Prior to treatment, dogs with FRE and IRE had a lower CD163+/CAL+ ratio than control dogs (CTRL) in crypts; this increased significantly and normalized compared with CTRL after treatment. Conversely, the CD163+/CAL+ ratio in dogs with ARE was comparable to that in healthy dogs before and after treatment. In summary, these results suggest that M? play a role in the pathogenesis of CE in FRE and IRE, with a decrease in resident M? and an increase in early differentiated M?, but not in ARE dogs. M? normalize after successful treatment.

SUBMITTER: Dandrieux JR 

PROVIDER: S-EPMC6830873 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment.

Dandrieux Julien Rs JR   Martinez Lopez Lina Maria LM   Stent Andrew A   Jergens Albert A   Allenspach Karin K   Nowell Cameron J CJ   Firestone Simon M SM   Kimpton Wayne W   Mansfield Caroline S CS  

Innate immunity 20180917 7


Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) - the latter most resembling inflammatory bowel disease in people. The aim of this study was to characterize duodenal macrophages (Mϕ) in CE using immunohistochemistry; with calprotectin (CAL) as a marker of early differentiated Mϕ and CD163 expression as a marker for resident Mϕ  ...[more]

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