Ontology highlight
ABSTRACT:
SUBMITTER: Waung MW
PROVIDER: S-EPMC6831085 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Waung Maggie W MW Margolis Elyssa B EB Charbit Annabelle R AR Fields Howard L HL
Cell reports 20190901 11
Migraines are a major health burden, but treatment is limited because of inadequate understanding of neural mechanisms underlying headache. Imaging studies of migraine patients demonstrate changes in both pain-modulatory circuits and reward-processing regions, but whether these changes contribute to the experience of headache is unknown. Here, we demonstrate a direct connection between the ventrolateral periaqueductal gray (vlPAG) and the ventral tegmental area (VTA) that contributes to headache ...[more]