Unknown

Dataset Information

0

A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.


ABSTRACT: BACKGROUND:To understand the clinical outcomes of selenium therapy in patients with sepsis syndrome, we conducted a meta-analysis of randomized controlled trials (RCT). METHODS:A total of 13 RCTs comparing selenium and placebo for patients with sepsis were reviewed systematically. RESULTS:However, we could not detect the association of selenium treatment with a decreased mortality at different time course (relative risk [RR] [95% confidence interval, CI]: 0.94 [0.82-1.06] at day 28; 0.73 [0.36-1.47] at day 90; 1.16 [0.78-1.71] at 6 months; respectively). Selenium supplementation did not show favorable efficacy in the incidence of renal failure, secondary infection or duration of mechanical ventilation (RR [95% CI]: 0.65 [0.41-1.03]; 0.96 [0.87-1.06]; standard mean difference [SMD] [95% CI]: 0.17 [-0.30-0.63]; respectively). Interestingly, we found that selenium therapy was benefit for sepsis patients with reduced duration of vasopressor therapy, staying time in intensive care unit and hospital, and incidence of ventilator-associated pneumonia (SMD [95% CI]: -0.75 [-1.37 to -0.13]; -0.15 [CI: -0.25 to -0.04]; -1.22 [-2.44 to -0.01]; RR [95% CI]: 0.61 [0.42-0.89]; respectively). CONCLUSION:Based on our findings, intravenous selenium supplementation could not be suggested for routine use.

SUBMITTER: Li S 

PROVIDER: S-EPMC6831114 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.

Li Shaojun S   Tang Tian T   Guo Pengfei P   Zou Qing Q   Ao Xiaoxiao X   Hu Lan L   Tan Liping L  

Medicine 20190301 9


<h4>Background</h4>To understand the clinical outcomes of selenium therapy in patients with sepsis syndrome, we conducted a meta-analysis of randomized controlled trials (RCT).<h4>Methods</h4>A total of 13 RCTs comparing selenium and placebo for patients with sepsis were reviewed systematically.<h4>Results</h4>However, we could not detect the association of selenium treatment with a decreased mortality at different time course (relative risk [RR] [95% confidence interval, CI]: 0.94 [0.82-1.06] a  ...[more]

Similar Datasets

| S-EPMC3055677 | biostudies-other
| S-EPMC4867648 | biostudies-other
| S-EPMC4990885 | biostudies-other
| S-EPMC4436191 | biostudies-literature
| S-EPMC9123731 | biostudies-literature
| S-EPMC7689899 | biostudies-literature
| S-EPMC2585120 | biostudies-other
| S-EPMC6024081 | biostudies-other
| S-EPMC5406747 | biostudies-literature
| S-EPMC7789676 | biostudies-literature