Ontology highlight
ABSTRACT:
SUBMITTER: Lv K
PROVIDER: S-EPMC6831299 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lv Kaiqi K Li Qingju Q Zhang Ling L Wang Yingchao Y Zhong Zhiwei Z Zhao Jing J Lin Xiaoxiao X Wang Jingyi J Zhu Keyang K Xiao Changchen C Ke Changle C Zhong Shuhan S Wu Xianpeng X Chen Jinghai J Yu Hong H Zhu Wei W Li Xiang X Wang Ben B Tang Ruikang R Wang Jian'an J Huang Jinyu J Hu Xinyang X
Theranostics 20191011 24
Bone marrow mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been widely used for treating myocardial infarction (MI). However, low retention and short-lived therapeutic effects are still significant challenges. This study aimed to determine whether incorporation of MSC-derived sEVs in alginate hydrogel increases their retention in the heart thereby improving therapeutic effects. <b>Methods:</b> The optimal sodium alginate hydrogel incorporating sEVs system was determ ...[more]