Unknown

Dataset Information

0

Associations Between Cognitive Functions and Physical Frailty in Patients With Parkinson's Disease.


ABSTRACT: Background: Parkinson's disease (PD) is a neurodegenerative disease manifested by both motor and non-motor dysfunctions and co-existence of cognitive impairment and physical frailty is common. Given that research in this area is limited, a better understanding of associated factors with physical frailty could provide a focused screening method and facilitate early intervention in PD. Methods: Seventy-six patients with idiopathic PD were recruited and Fried's criteria of physical frailty were used to group all participants. Comprehensive cognitive tests and clinical characteristics were measured, and univariate and multivariate analysis was performed to explore the relationship between clinical factors or neuropsychological functions. Results: Twenty-nine patients with PD (38%) exhibited physical frailty. Compared to PD patients without frailty, PD patients with frailty were older in age and demonstrated worse disease severity and poorer cognitive functions, including attention, executive function, memory, speech and language, and visuospatial function (p < 0.05). Further, stepwise logistic regression analysis revealed that disease severity by the Unified Parkinson's Disease Rating Scale (UPDRS) total score (OR: 1.065; 95% CI: 1.033-1.099) and executive function (OR: 0.724; 95% CI: 0.581-0.877) were independent risk factors for predicting physical frailty (p = 0.003 and 0.002). The best cut-off points are 46 in UPDRS (sensitivity: 62.1%; specificity: 91.5%). Conclusions: Executive function impairment is an independent risk factor for the development of physical frailty with disease progression. Awareness of such comorbidity might provide a screening tool to facilitate investigation in their underlying etiology and early intervention for frailty prevention.

SUBMITTER: Lin WC 

PROVIDER: S-EPMC6831640 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

altmetric image

Publications

Associations Between Cognitive Functions and Physical Frailty in Patients With Parkinson's Disease.

Lin Wei-Che WC   Huang Yu-Chi YC   Leong Chau-Peng CP   Chen Meng-Hsiang MH   Chen Hsiu-Ling HL   Tsai Nai-Wen NW   Tso Hui-Hsin HH   Chen Po-Cheng PC   Lu Cheng-Hsien CH  

Frontiers in aging neuroscience 20191030


<b>Background</b>: Parkinson's disease (PD) is a neurodegenerative disease manifested by both motor and non-motor dysfunctions and co-existence of cognitive impairment and physical frailty is common. Given that research in this area is limited, a better understanding of associated factors with physical frailty could provide a focused screening method and facilitate early intervention in PD. <b>Methods</b>: Seventy-six patients with idiopathic PD were recruited and Fried's criteria of physical fr  ...[more]

Similar Datasets

| S-EPMC5474720 | biostudies-literature
| S-EPMC7447860 | biostudies-literature
| S-EPMC6174444 | biostudies-literature
| S-EPMC7069469 | biostudies-literature
| S-EPMC8710786 | biostudies-literature
| S-EPMC8463514 | biostudies-literature
| S-EPMC6261587 | biostudies-literature
| S-EPMC4958972 | biostudies-literature
| S-EPMC7160316 | biostudies-literature
| S-EPMC6660222 | biostudies-literature