Ontology highlight
ABSTRACT:
SUBMITTER: Fish EW
PROVIDER: S-EPMC6831672 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Fish Eric W EW Murdaugh Laura B LB Zhang Chengjin C Boschen Karen E KE Boa-Amponsem Oswald O Mendoza-Romero Haley N HN Tarpley Michael M Chdid Lhoucine L Mukhopadhyay Somnath S Cole Gregory J GJ Williams Kevin P KP Parnell Scott E SE
Scientific reports 20191105 1
We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, and explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling. The CBs, Δ<sup>9</sup>-THC, cannabidiol, HU-210, and CP 55,940 caused alcohol-like effects on craniofacial and brain development, phenocopying Shh mutations. Combined exposure to even low doses of alcohol with THC, HU-210, or CP 55,940 caused a greater incidence of birth defects, particularly of the eyes, than di ...[more]