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Collagen turnover profiles in chronic kidney disease.

ABSTRACT: Renal fibrosis is a hallmark of chronic kidney disease (CKD) caused by an imbalance between formation and degradation of extracellular matrix proteins. We investigated the collagen turnover profile of 81 non-dialysis CKD stage 2-5 patients by measuring peptides reflecting formation and degradation of collagen type (COL) I, III, IV, and VI. Based on the collagen turnover profile, we identified four clusters of patients. Cluster 1 contained one patient with prostate cancer, who had a distinct collagen turnover. The other clusters generally had severe (Cluster 2), moderate (Cluster 4), or mild CKD (Cluster 3). Cluster 4 patients were characterized by higher levels of COL III, COL IV, and COL VI (all p?

SUBMITTER: Rasmussen DGK

PROVIDER: S-EPMC6831687 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Collagen turnover profiles in chronic kidney disease.

Rasmussen Daniel Guldager Kring DGK Boesby Lene L Nielsen Signe Holm SH Tepel Martin M Birot Sophie S Karsdal Morten Asser MA Kamper Anne-Lise AL Genovese Federica F

Scientific reports 20191105 1

Renal fibrosis is a hallmark of chronic kidney disease (CKD) caused by an imbalance between formation and degradation of extracellular matrix proteins. We investigated the collagen turnover profile of 81 non-dialysis CKD stage 2-5 patients by measuring peptides reflecting formation and degradation of collagen type (COL) I, III, IV, and VI. Based on the collagen turnover profile, we identified four clusters of patients. Cluster 1 contained one patient with prostate cancer, who had a distinct coll ...[more]

PMID: 31690732

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Methylation profiles of Chronic kidney disease

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Imbalanced turnover of collagen type III is associated with disease progression and mortality in high-risk chronic kidney disease patients.

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| S-EPMC7886548 | biostudies-literature

Gene expression profiles of Chronic kidney disease

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2013-07-18 | E-GEOD-48944 | biostudies-arrayexpress

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