Ontology highlight
ABSTRACT:
SUBMITTER: Hia F
PROVIDER: S-EPMC6831995 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Hia Fabian F Yang Sheng Fan SF Shichino Yuichi Y Yoshinaga Masanori M Murakawa Yasuhiro Y Vandenbon Alexis A Fukao Akira A Fujiwara Toshinobu T Landthaler Markus M Natsume Tohru T Adachi Shungo S Iwasaki Shintaro S Takeuchi Osamu O
EMBO reports 20190903 11
Codon bias has been implicated as one of the major factors contributing to mRNA stability in several model organisms. However, the molecular mechanisms of codon bias on mRNA stability remain unclear in humans. Here, we show that human cells possess a mechanism to modulate RNA stability through a unique codon bias. Bioinformatics analysis showed that codons could be clustered into two distinct groups-codons with G or C at the third base position (GC3) and codons with either A or T at the third ba ...[more]