MTNR1B genetic polymorphisms as risk factors for gestational diabetes mellitus: a case-control study in a single tertiary care center.

ABSTRACT: BACKGROUND:Gestational diabetes mellitus (GDM) is a metabolic disease in pregnancy that causes carbohydrate intolerance and hyper-glycemia. Genome-wide association studies and meta-analyses have found that the single nucleotide polymorphisms (SNPs) rs1387153 and rs10830963 of the melatonin receptor 1B ( MTNR1B) gene are associated with GDM. No studies on the MTNR1B gene effect on GDM have been performed in Saudis, other Arabs, or other Middle Eastern populations. OBJECTIVES:Investigate the association of genotype or allele frequencies of the two SNPs with GDM and with clinical parameters related to GDM. DESIGN:Case-control study. SETTINGS:Tertiary care center, Riyadh. PATIENTS AND METHODS:We recruited 400 pregnant Saudi women ages 18-45 years (200 were diagnosed with GDM, and 200 were heal

SUBMITTER: Alharbi KK 

PROVIDER: S-EPMC6832319 | biostudies-literature | 2019 Sep-Oct

REPOSITORIES: biostudies-literature