Ontology highlight
ABSTRACT:
SUBMITTER: Cheng J
PROVIDER: S-EPMC6832359 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cheng Jinlong J Zhao Ye Y Xu Gang G Zhang Keran K Jia Wenfeng W Sun Yali Y Zhao Jing J Xue Jia J Hu Yanxin Y Zhang Guozhong G
Viruses 20191022 10
Some coronaviruses (CoVs) have an extra furin cleavage site (RRKR/S, furin-S2' site) upstream of the fusion peptide in the spike protein, which plays roles in virion adsorption and fusion. Mutation of the S2' site of QX genotype (QX-type) infectious bronchitis virus (IBV) spike protein (S) in a recombinant virus background results in higher pathogenicity, pronounced neural symptoms and neurotropism when compared with conditions in wild-type IBV (WT-IBV) infected chickens. In this study, we prese ...[more]