Ontology highlight
ABSTRACT:
SUBMITTER: Tarr GAM
PROVIDER: S-EPMC6832461 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Tarr Gillian A M GAM Stokowski Taryn T Shringi Smriti S Tarr Phillip I PI Freedman Stephen B SB Oltean Hanna N HN Rabinowitz Peter M PM Chui Linda L
Toxins 20191018 10
<i>Escherichia coli</i> O157:H7 is the predominant cause of diarrhea-associated hemolytic uremic syndrome (HUS) worldwide. Its cardinal virulence traits are Shiga toxins, which are encoded by <i>stx</i> genes, the most common of which are <i>stx1a</i>, <i>stx2a</i>, and <i>stx2c.</i> The toxins these genes encode differ in their in vitro and experimental phenotypes, but the human population-level impact of these differences is poorly understood. Using Shiga toxin-encoding bacteriophage insertion ...[more]