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Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life.


ABSTRACT: Neonates often develop poor immunity against intracellular pathogens. Because CD8+ T cells are essential for eliminating infectious agents, it is crucial to understand why they behave differently in early life. Previous studies in mice have demonstrated that neonatal CD8+ T cells fail to form memory because of an intrinsic propensity to differentiate into short-lived effectors. However, the underlying mechanisms remain undefined. We now show that neonatal CD8+ T cells exhibit higher glycolytic activity than adult CD8+ T cells postinfection, which may be due to age-related differences in Lin28b expression. Importantly, when glycolysis is pharmacologically inhibited, the impaired formation of neonatal memory CD8+ T cells can be restored. Collectively, these data suggest that neonatal CD8+ T cells are inherently biased toward undergoing glycolytic metabolism postinfection, which compromises their ability to develop into memory CD8+ T cells in early life.

SUBMITTER: Tabilas C 

PROVIDER: S-EPMC6832862 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8<sup>+</sup> T Cells in Early Life.

Tabilas Cybelle C   Wang Jocelyn J   Liu Xiaojing X   Locasale Jason W JW   Smith Norah L NL   Rudd Brian D BD  

Journal of immunology (Baltimore, Md. : 1950) 20191009 10


Neonates often develop poor immunity against intracellular pathogens. Because CD8<sup>+</sup> T cells are essential for eliminating infectious agents, it is crucial to understand why they behave differently in early life. Previous studies in mice have demonstrated that neonatal CD8<sup>+</sup> T cells fail to form memory because of an intrinsic propensity to differentiate into short-lived effectors. However, the underlying mechanisms remain undefined. We now show that neonatal CD8<sup>+</sup> T  ...[more]

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