Ontology highlight
ABSTRACT:
SUBMITTER: Tabilas C
PROVIDER: S-EPMC6832862 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Tabilas Cybelle C Wang Jocelyn J Liu Xiaojing X Locasale Jason W JW Smith Norah L NL Rudd Brian D BD
Journal of immunology (Baltimore, Md. : 1950) 20191009 10
Neonates often develop poor immunity against intracellular pathogens. Because CD8<sup>+</sup> T cells are essential for eliminating infectious agents, it is crucial to understand why they behave differently in early life. Previous studies in mice have demonstrated that neonatal CD8<sup>+</sup> T cells fail to form memory because of an intrinsic propensity to differentiate into short-lived effectors. However, the underlying mechanisms remain undefined. We now show that neonatal CD8<sup>+</sup> T ...[more]