A cross-sectional survey of adrenal steroid hormones among overweight/obese boys according to puberty stage.

ABSTRACT: BACKGROUND:Obesity is associated with many chronic diseases including cortisol rhythm disorder and low testosterone. Furthermore, studies on obese children are quite limited and no concordance results have been obtained, especially for boys in puberty. Moreover, the sample sizes of previous studies were small, and were not representative. METHODS:We conducted a cross-sectional survey including 1148 boys aged 6-14?years, they were divided into overweight/obesity (OW/OB) group and normal weight (NW) group. Puberty status was assessed according to Tanner scale and testicular volume. Serum levels of pregnenolone, 17-OH progesterone, corticosterone, dehydroepiandrosterone (DHEA), and androstenedione were detected by LC-MS. Serum free testosterone and sex hormone-binding globulin (SHBG) levels were measured by chemiluminescence immunoassay. RESULTS:The 17-OH progesterone, DHEA, androstenedione and free testosterone levels of OW/OB boys at prepubertal stage or at the age 6?=?

SUBMITTER: Cao B 

PROVIDER: S-EPMC6833276 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature