Ontology highlight
ABSTRACT:
SUBMITTER: Hannon BG
PROVIDER: S-EPMC6833323 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Hannon Bailey G BG Schwaner Stephen A SA Boazak Elizabeth M EM Gerberich Brandon G BG Winger Erin J EJ Prausnitz Mark R MR Ethier C Ross CR
Journal of the Royal Society, Interface 20191016 159
Scleral stiffening has been proposed as a therapy for glaucoma and myopia. Previous <i>in vivo</i> studies have evaluated the efficacy of scleral stiffening after multiple treatments with a natural collagen crosslinker, genipin. However, multiple injections limit clinical translatability. Here, we examined whether scleral stiffening was maintained after four weeks following a single genipin treatment. Eyes from brown Norway rats were treated <i>in vivo</i> with a single 15 mM genipin retrobulbar ...[more]