Pre-transplantation Risks and Transplant-Techniques in Haematopoietic Stem Cell Transplantation for Acute Leukaemia.

ABSTRACT: Background:The role of conditioning intensity and stem cell source on modifying pre-transplantation risk in allogeneic haematopoietic stem cell transplantation (HSCT) is a matter of debate, but crucial when benchmarking centres. Methods:This Retrospective, multicenter exploratory-validation analysis of 9103 patients, (55.5% male, median age 50?years; 1-75?years range) with an allogeneic HSCT between 2010 and 2016 from a matched sibling (N?=?8641; 95%) or matched unrelated donor (N?=?462; 5%) for acute myeloid (N?=?6432; 71%) or acute lymphoblastic (N?=?2671; 29%) leukaemia in first complete remission, and reported by 240 centres in 30 countries to the benchmark database of the European Society for Blood and Marrow Transplantation (EBMT) searched for factors associated with use of transplant techniques (standard N?=?6375;70% or reduced intensity conditioning N?=?2728;30%, respectively bone marrow N?=?1945;21% or peripheral blood N?=?7158;79% as stem cell source), and their impact on outcome. Findings:Treatment groups differed significantly from baseline population (p?

SUBMITTER: Gratwohl A 

PROVIDER: S-EPMC6833359 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature