Ontology highlight
ABSTRACT:
SUBMITTER: Mekni N
PROVIDER: S-EPMC6834175 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Mekni Nedra N De Rosa Maria M Cipollina Chiara C Gulotta Maria Rita MR De Simone Giada G Lombino Jessica J Padova Alessandro A Perricone Ugo U
International journal of molecular sciences 20191009 20
NLRP3 (NOD-like receptor family, pyrin domain-containing protein 3) activation has been linked to several chronic pathologies, including atherosclerosis, type-II diabetes, fibrosis, rheumatoid arthritis, and Alzheimer's disease. Therefore, NLRP3 represents an appealing target for the development of innovative therapeutic approaches. A few companies are currently working on the discovery of selective modulators of NLRP3 inflammasome. Unfortunately, limited structural data are available for this t ...[more]