Ontology highlight
ABSTRACT:
SUBMITTER: Pino M
PROVIDER: S-EPMC6834281 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Pino Maria M Paganini Sara S Deleage Claire C Padhan Kartika K Harper Justin L JL King Colin T CT Micci Luca L Cervasi Barbara B Mudd Joseph C JC Gill Kiran P KP Jean Sherrie M SM Easley Kirk K Silvestri Guido G Estes Jacob D JD Petrovas Constantinos C Lederman Michael M MM Paiardini Mirko M
PLoS pathogens 20191018 10
Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells in LN of cART-suppressed, SIV-infected rhesus macaques by treatment with the lysophospholipid sphingosine-1 phosphate receptor modulator FTY720 (fingolimod). FTY720 was remarkably effective in reducing ...[more]