25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.
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ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC6834473 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.
Wang Saisai S Yao Yuanyuan Y Wang Xiao X Zheng Gang G Ouyang Wei W Chen Wenbin W
American journal of cancer research 20191001 10
Metabolic syndrome is a significant risk factor for the development of hepatocellular carcinoma (HCC). 25-HC (25-hydroxycholesterol) synthesized from cholesterol plays an important role in lipid metabolism. However, the functions and mechanism of 25-HC in HCC remain largely unknown. In this study, we demonstrated that 25-HC promoted HCC cells migration and intrahepatic and extrahepatic metastasis while did not affect the cells proliferation and apoptosis. Mechanistically, the promotive effect of ...[more]
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