Ontology highlight
ABSTRACT:
SUBMITTER: Meng F
PROVIDER: S-EPMC6834558 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Nature communications 20191106 1
The molecular mechanisms driving metastatic progression in triple-negative breast cancer (TNBC) patients are poorly understood. In this study, we demonstrate that epidermal growth factor-like 9 (EGFL9) is significantly upregulated in basal-like breast cancer cells and associated with metastatic progression in breast tumor samples. Functionally, EGFL9 is both necessary and sufficient to enhance cancer cell migration and invasion, as well as distant metastasis. Mechanistically, we demonstrate that ...[more]