Transcriptomic Analysis of mRNA-lncRNA-miRNA Interactions in Hepatocellular Carcinoma.
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ABSTRACT:
SUBMITTER: Tang X
PROVIDER: S-EPMC6834564 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Transcriptomic Analysis of mRNA-lncRNA-miRNA Interactions in Hepatocellular Carcinoma.
Tang Xia X Feng Delong D Li Min M Zhou Jinxue J Li Xiaoyuan X Zhao Dachun D Hao Bingtao B Li Dewei D Ding Keyue K
Scientific reports 20191106 1
Fully elucidating the molecular mechanisms of non-coding RNAs (ncRNAs), including micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs), underlying hepatocarcinogenesis is challenging. We characterized the expression profiles of ncRNAs and constructed a regulatory mRNA-lncRNA-miRNA (MLMI) network based on transcriptome sequencing (RNA-seq) of hepatocellular carcinoma (HCC, n = 9) patients. Of the identified miRNAs (n = 203) and lncRNAs (n = 1,090), we found 16 significantly differentially expre ...[more]
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