Ontology highlight
ABSTRACT:
SUBMITTER: Yan Y
PROVIDER: S-EPMC6835201 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Yan Yuqian Y Ma Jian J Wang Dejie D Lin Dong D Pang Xiaodong X Wang Shangqian S Zhao Yu Y Shi Lei L Xue Hui H Pan Yunqian Y Zhang Jun J Wahlestedt Claes C Giles Francis J FJ Chen Yu Y Gleave Martin E ME Collins Collin C CC Ye Dingwei D Wang Yuzhuo Y Huang Haojie H
EMBO molecular medicine 20190926 11
CULLIN3-based E3 ubiquitin ligase substrate-binding adaptor gene SPOP is frequently mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (e.g., F133V) are resistant to BET inhibitors because of aberrant elevation of BET proteins. Here, we identified a previously unrecognized mutation Q165P at the edge of SPOP MATH domain in primary and metastatic PCa of a patient. The Q165P mutation causes structural changes in the MATH domain and impairs SPOP dimerization and substrate degradati ...[more]