Ontology highlight
ABSTRACT:
SUBMITTER: Araujo AM
PROVIDER: S-EPMC6835778 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Araújo Ana Margarida AM Enea Maria M Carvalho Félix F Bastos Maria de Lourdes ML Carvalho Márcia M Guedes de Pinho Paula P
Metabolites 20191015 10
<h4>Background and aims</h4>Liver toxicity is a well-documented and potentially fatal adverse complication of hyperthermia. However, the impact of hyperthermia on the hepatic metabolome has hitherto not been investigated.<h4>Methods</h4>In this study, gas chromatography-mass spectrometry (GC-MS)-based metabolomics was applied to assess the in vitro metabolic response of primary mouse hepatocytes (PMH, <i>n</i> = 10) to a heat stress stimulus, i.e., after 24 h exposure to 40.5 °C. Metabolomic pro ...[more]