Dataset Information

MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation.

ABSTRACT: Magnetic particle imaging (MPI) is a new imaging technique that detects the spatial distribution of magnetic nanoparticles (MNP) with the option of high temporal resolution. MPI relies on particular MNP as tracers with tailored characteristics for improvement of sensitivity and image resolution. For this reason, we developed optimized multicore particles (MCP 3) made by coprecipitation via synthesis of green rust and subsequent oxidation to iron oxide cores consisting of a magnetite/maghemite mixed phase. MCP 3 shows high saturation magnetization close to that of bulk maghemite and provides excellent magnetic particle spectroscopy properties which are superior to Resovist^® and any other up to now published MPI tracers made by coprecipitation. To evaluate the MPI characteristics of MCP 3 two kinds of tube phantoms were prepared and investigated to assess sensitivity, spatial resolution, artifact severity, and selectivity. Resovist^® was used as standard of comparison. For image reconstruction, the regularization factor was optimized, and the resulting images were investigated in terms of quantifying of volumes and iron content. Our results demonstrate the superiority of MCP 3 over Resovist^® for all investigated MPI characteristics and suggest that MCP 3 is promising for future experimental in vivo studies.

SUBMITTER: Kratz H

PROVIDER: S-EPMC6835925 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:The present study examines the prevalence, localization, frequency, and intensity of playing-related pain (PRP) in a sample of high-performing young musicians. We also address coping behavior and communication about PRP between young musicians, teachers, parents, and other people, such as friends. The aim is to provide information on PRP among high-performing musicians in childhood and adolescence, which can serve as a basis for music education, practice, and prevention in the context of instrumental teaching and musicians' health. The study is part of a large-scale study (N = 1,143) with highly musically gifted participants (age 9-24 years; M = 15.1; SD = 2.14, female = 62%) at the national level of the "Jugend musiziert" (youth making music) contest. For data analyses, we used descriptive statistics, correlations, Chi2-tests, principal component analysis, Kruskal-Wallis H tests, and multivariate regression. About three-quarters (76%) of the surveyed participants stated that they had experienced pain during or after playing their instrument. Female musicians were significantly more frequently affected (79%) than male musicians (71%). With increasing age, the prevalence of PRP rises from 71 percent (9-13 years) to 85 percent (18-24 years). Regarding localization of pain, results are in line with many other studies with musculoskeletal problems the most common. Furthermore, data show a clear relationship between the duration of practice and the prevalence of PRP. Our study found averages of 7:18 h/week, whereas mean values of the duration of practice vary considerably between different instruments. The variance in practice duration is very large within the different instruments. Thus, when researching PRP, it is necessary to consider both the differences between different groups of instruments in the average duration of practice as well as the very large inter-individual variation in the duration of practice within a given instrument group. While just over half of the young musicians (56%) felt they had been taken seriously, 32 percent felt that their complaints were not completely taken seriously, and 12 percent did not feel taken seriously at all. Therefore, it is necessary to improve communication and information about PRP to prevent PRP and counteract existing complaints.

Dataset Information

MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets