Dataset Information

Identification and Structural Elucidation of Anti-Inflammatory Compounds from Chinese Olive (Canarium Album L.) Fruit Extracts.

ABSTRACT: Chinese olive (Canarium album L.), a rich source of polyphenols, can be used as a functional food ingredient. We previously showed that the ethyl acetate fraction of this extract (CO-EtOAc) is an effective anti-inflammatory agent. Therefore, here, we aimed to screen the bioactive fractions extracted from CO-EtOAc using different isolation techniques, and purify the bioactive compounds based on their cytotoxic and anti-inflammatory abilities. CO-EtOAc was fractionated using silica gel and Sephadex column chromatography, and the active compounds were isolated and purified by high-performance liquid chromatography (HPLC). The structures of the resulting compounds were identified using proton nuclear magnetic resonance (NMR) spectra. Activity-directed fractionation and purification were used to identify the following active compounds with anti-inflammatory effects using lipopolysaccharide (LPS)-stimulated mouse macrophages: sitoindoside I, amentoflavone, tetrahydroamentoflavone and protocatechuic acid. For the first time, sitoindoside I and tetrahydroamentoflavone were isolated from Chinese olive, and the anti-inflammatory compounds of CO-EtOAc were identified, suggesting its potential for used as a health food ingredient.

SUBMITTER: Kuo YH

PROVIDER: S-EPMC6836117 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Identification and Structural Elucidation of Anti-Inflammatory Compounds from Chinese Olive (<i>Canarium Album</i> L.) Fruit Extracts.

Kuo Yueh-Hsiung YH Yeh Yu-Te YT Pan Sih-Ying SY Hsieh Shu-Chen SC

Foods (Basel, Switzerland) 20190926 10

Chinese olive (<i>Canarium album</i> L.), a rich source of polyphenols, can be used as a functional food ingredient. We previously showed that the ethyl acetate fraction of this extract (CO-EtOAc) is an effective anti-inflammatory agent. Therefore, here, we aimed to screen the bioactive fractions extracted from CO-EtOAc using different isolation techniques, and purify the bioactive compounds based on their cytotoxic and anti-inflammatory abilities. CO-EtOAc was fractionated using silica gel and ...[more]

PMID: 31561441

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Dataset Information

Identification and Structural Elucidation of Anti-Inflammatory Compounds from Chinese Olive (Canarium Album L.) Fruit Extracts.

Publications

Identification and Structural Elucidation of Anti-Inflammatory Compounds from Chinese Olive (<i>Canarium Album</i> L.) Fruit Extracts.

Similar Datasets

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