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Application of MALDI-TOF MS to rapid identification of anaerobic bacteria.


ABSTRACT: BACKGROUND:Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been rapidly developed and widely used as an analytical technique in clinical laboratories with high accuracy in microorganism identification. OBJECTIVE:To validate the efficacy of MALDI-TOF MS in identification of clinical pathogenic anaerobes. METHODS:Twenty-eight studies covering 6685 strains of anaerobic bacteria were included in this meta-analysis. Fixed-effects models based on the P-value and the I-squared were used for meta-analysis to consider the possibility of heterogeneity between studies. Statistical analyses were performed by using STATA 12.0. RESULTS:The identification accuracy of MALDI-TOF MS was 84% for species (I2?=?98.0%, P?

SUBMITTER: Li Y 

PROVIDER: S-EPMC6836477 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Application of MALDI-TOF MS to rapid identification of anaerobic bacteria.

Li Ying Y   Shan Mingzhu M   Zhu Zuobin Z   Mao Xuhua X   Yan Mingju M   Chen Ying Y   Zhu Qiuju Q   Li Hongchun H   Gu Bing B  

BMC infectious diseases 20191107 1


<h4>Background</h4>Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been rapidly developed and widely used as an analytical technique in clinical laboratories with high accuracy in microorganism identification.<h4>Objective</h4>To validate the efficacy of MALDI-TOF MS in identification of clinical pathogenic anaerobes.<h4>Methods</h4>Twenty-eight studies covering 6685 strains of anaerobic bacteria were included in this meta-analysis. Fixed-effects m  ...[more]

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