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Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids.

ABSTRACT: Herein, we report three-component vicinal-diarylation of non-conjugated alkenes initiated by transmetalation of arylboronic acids, which provides complementary access to ?,?-diaryl carbonyl compounds. We have also screened a large number of chiral ligands for developing an enantioselective version of this reaction and obtained the preliminary results (up to 79?:?21 e.r.). Notably, the methodology developed herein represents the first three component syn-vicinal-dicarbofunctionalization of non-conjugated alkenes involving palladium catalysis.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC6836572 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids.

Zhang Yun Y Chen Gong G Zhao Dongbing D

Chemical science 20190703 34

Herein, we report three-component vicinal-diarylation of non-conjugated alkenes initiated by transmetalation of arylboronic acids, which provides complementary access to β,γ-diaryl carbonyl compounds. We have also screened a large number of chiral ligands for developing an enantioselective version of this reaction and obtained the preliminary results (up to 79 : 21 e.r.). Notably, the methodology developed herein represents the first three component syn-vicinal-dicarbofunctionalization of ...[more]

PMID: 31853350

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