Dataset Information

The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis.

ABSTRACT: Hyperuricemia coincides with coronary artery calcification (CAC) development, but the role of serum uric acid (SUA) as a risk factor for CAC remains unclear. The objective of this study was to gain an insight into the association between SUA and CAC in adults by performing a meta-analysis. MEDLINE, EMBASE, the Cochrane Library, and EBSCO (CINAHL) were searched for relevant observational studies published until 2 June 2019. Studies were included only if they reported data on CAC presence (Agatston score?>?0) or progression related to hyperuricemia in subclinical adult patients. The pooled estimates of crude and adjusted odds ratios (ORs) and 95% confidence interval (CI) were calculated to evaluate the association between CAC presence or progression and hyperuricemia. A total of 11 studies were identified involving 11?108 adults. The pooled OR based on the frequency of CAC presence showed that patients in the high SUA group had 1.806-fold risk for developing CAC (95% CI: 1.491-2.186) under the minimal threshold of hyperuricemia (more than 6 mg/dL or 357??moL/L). When SUA levels were analyzed as categorical variables, the pooled estimate of adjusted ORs was 1.48 (95% CI: 1.23-1.79) for CAC presence. Additionally, for each increase of 1 mg/dL of SUA level, the risk of CAC progression was increased by 31% (95% CI: 1.15-1.49) with an average follow-up duration ranged from 4.6 to 6.1?years. Hyperuricemia is closely associated with increased risk of CAC development and CAC progression in asymptomatic patients.

SUBMITTER: Liang L

PROVIDER: S-EPMC6837029 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis.

Liang Ling L Hou Xianghua X Bainey Kevin R KR Zhang Yanlin Y Tymchak Wayne W Qi Zhongquan Z Li Weihua W Banh Hoan Linh HL

Clinical cardiology 20190930 11

Hyperuricemia coincides with coronary artery calcification (CAC) development, but the role of serum uric acid (SUA) as a risk factor for CAC remains unclear. The objective of this study was to gain an insight into the association between SUA and CAC in adults by performing a meta-analysis. MEDLINE, EMBASE, the Cochrane Library, and EBSCO (CINAHL) were searched for relevant observational studies published until 2 June 2019. Studies were included only if they reported data on CAC presence (Agatsto ...[more]

PMID: 31571239

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Dataset Information

The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis.

Publications

The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis.

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