Ontology highlight
ABSTRACT:
SUBMITTER: Quiroz JA
PROVIDER: S-EPMC6837291 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Quiroz Jose A JA Malonis Ryan J RJ Thackray Larissa B LB Cohen Courtney A CA Pallesen Jesper J Jangra Rohit K RK Brown Rebecca S RS Hofmann Daniel D Holtsberg Frederick W FW Shulenin Sergey S Nyakatura Elisabeth K EK Durnell Lorellin A LA Rayannavar Vinayak V Daily Johanna P JP Ward Andrew B AB Aman M Javad MJ Dye John M JM Chandran Kartik K Diamond Michael S MS Kielian Margaret M Lai Jonathan R JR
PLoS pathogens 20191107 11
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHIKV in the Dominican Republic. Single B cell sorting yielded a panel of 46 human mAbs of diverse germline lineages that targeted epitopes within the E1 or E2 glycoproteins. MAbs that recognized either E1 or E2 proteins exhibited neutralizing activity. ...[more]