Morphological MRI phenotypes of multiple sclerosis differ in resting-state brain function.
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ABSTRACT:
SUBMITTER: Pinter D
PROVIDER: S-EPMC6838050 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Morphological MRI phenotypes of multiple sclerosis differ in resting-state brain function.
Pinter Daniela D Beckmann Christian F CF Fazekas Franz F Khalil Michael M Pichler Alexander A Gattringer Thomas T Ropele Stefan S Fuchs Siegrid S Enzinger Christian C
Scientific reports 20191107 1
We aimed to assess differences in resting-state functional connectivity (FC) between distinct morphological MRI-phenotypes in multiple sclerosis (MS). Out of 180 MS patients, we identified those with high T2-hyperintense lesion load (T2-LL) and high normalized brain volume (NBV; a predominately white matter damage group, WMD; N = 37) and patients with low T2-LL and low NBV (N = 37; a predominately grey matter damage group; GMD). Independent component analysis of resting-state fMRI was used to te ...[more]
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