Ontology highlight
ABSTRACT:
SUBMITTER: Xie Y
PROVIDER: S-EPMC6838200 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Xie Ying Y Sun Jialin J Han Xiao X Turšić-Wunder Alma A Toh Joel D W JDW Hong Wanjin W Gao Yong-Gui YG Miao Yansong Y
Nature communications 20191107 1
A multiprotein complex polarisome nucleates actin cables for polarized cell growth in budding yeast and filamentous fungi. However, the dynamic regulations of polarisome proteins in polymerizing actin under physiological and stress conditions remains unknown. We identify a previously functionally unknown polarisome member, actin-interacting-protein 5 (Aip5), which promotes actin assembly synergistically with formin Bni1. Aip5-C terminus is responsible for its activities by interacting with G-act ...[more]