Plant-Derived Exosomal Nanoparticles Inhibit Pathogenicity of Porphyromonas gingivalis.
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ABSTRACT:
SUBMITTER: Sundaram K
PROVIDER: S-EPMC6838522 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Plant-Derived Exosomal Nanoparticles Inhibit Pathogenicity of Porphyromonas gingivalis.
Sundaram Kumaran K Miller Daniel P DP Kumar Anil A Teng Yun Y Sayed Mohammed M Mu Jingyao J Lei Chao C Sriwastva Mukesh K MK Zhang Lifeng L Yan Jun J Merchant Michael L ML He Liqing L Fang Yuan Y Zhang Shuangqin S Zhang Xiang X Park Juw W JW Lamont Richard J RJ Zhang Huang-Ge HG
iScience 20191021
Plant exosomes protect plants against infection; however, whether edible plant exosomes can protect mammalian hosts against infection is not known. In this study, we show that ginger exosome-like nanoparticles (GELNs) are selectively taken up by the periodontal pathogen Porphyromonas gingivalis in a GELN phosphatidic acid (PA) dependent manner via interactions with hemin-binding protein 35 (HBP35) on the surface of P. gingivalis. Compared with PA (34:2), PA (34:1) did not interact with HBP35, in ...[more]
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