Ontology highlight
ABSTRACT:
SUBMITTER: Adriaenssens AE
PROVIDER: S-EPMC6838660 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Cell metabolism 20190822 5
Ambiguity regarding the role of glucose-dependent insulinotropic polypeptide (GIP) in obesity arises from conflicting reports asserting that both GIP receptor (GIPR) agonism and antagonism are effective strategies for inhibiting weight gain. To enable identification and manipulation of Gipr-expressing (Gipr) cells, we created Gipr-Cre knockin mice. As GIPR-agonists have recently been reported to suppress food intake, we aimed to identify central mediators of this effect. Gipr cells were identifi ...[more]