Ontology highlight
ABSTRACT:
SUBMITTER: Streby KA
PROVIDER: S-EPMC6838937 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Streby Keri A KA Currier Mark A MA Triplet Melinda M Ott Kristy K Dishman Devon J DJ Vaughan Michele R MR Ranalli Mark A MA Setty Bhuvana B Skeens Micah A MA Whiteside Stacy S Yeager Nicholas D ND Haworth Kellie B KB Simpson Kathleen K Conner Joe J Cripe Timothy P TP
Molecular therapy : the journal of the American Society of Gene Therapy 20190910 11
Seprehvir (HSV1716) is an oncolytic herpes simplex virus-1 (HSV-1) previously demonstrated to be well tolerated in pediatric patients when administered intratumorally. To determine the safety of administering Seprehvir systemically, we conducted the first-in-human phase I trial of intravenous injection in young patients with relapsed or refractory extra-cranial solid cancers. We delivered a single dose of 5 × 10<sup>4</sup> infectious units (iu)/kg (maximum dose of 2 × 10<sup>6</sup>) or 2.5 × 1 ...[more]