Dataset Information

Modifiable Risk Factors Explain Socioeconomic Inequalities in Dementia Risk: Evidence from a Population-Based Prospective Cohort Study.

ABSTRACT:

Background

Differences in dementia risk across the gradient of socioeconomic status (SES) exist, but their determinants are not well understood.

Objective

This study investigates whether health conditions and lifestyle-related risk factors explain the SES inequalities in dementia risk.

Methods

6,346 participants from the English Longitudinal Study of Ageing were followed up from 2008/2009 until 2014/2015. We used Cox regression adjusted for age, gender, wealth/education, and clustering at the household level to examine the association between SES markers (wealth, education) and time to dementia in a structural equation model including potential mediation or effect modification by a weighted compound score of twelve modifiable risk and protective factors for dementia ('LIfestyle for BRAin health' (LIBRA) score).

Results

During a median follow-up of 6 years, 192 individuals (3.0%) developed dementia. LIBRA scores decreased with increasing wealth and higher educational level. A one-point increase in the LIBRA score was associated with a 13% increase in dementia risk (hazard ratio (HR)?=?1.13, 95% confidence interval 1.07-1.19). Higher wealth was associated with a decreased dementia risk (HR?=?0.58, 0.39-0.85). Mediation analysis showed that 52% of the risk difference between the highest and lowest wealth tertile was mediated by differences in LIBRA (indirect effect: HR?=?0.75, 0.66-0.85). Education was not directly associated with dementia (HR?=?1.05, 0.69-1.59), but was a distal risk factor for dementia by explaining differences in wealth and LIBRA scores (indirect effect high education: HR?=?0.92, 0.88-0.95).

Conclusion

Socioeconomic differences in dementia risk can be partly explained by differences in modifiable health conditions and lifestyle factors.

SUBMITTER: Deckers K

PROVIDER: S-EPMC6839472 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Modifiable Risk Factors Explain Socioeconomic Inequalities in Dementia Risk: Evidence from a Population-Based Prospective Cohort Study.

Deckers Kay K Cadar Dorina D van Boxtel Martin P J MPJ Verhey Frans R J FRJ Steptoe Andrew A Köhler Sebastian S

Journal of Alzheimer's disease : JAD 20190101 2

<h4>Background</h4>Differences in dementia risk across the gradient of socioeconomic status (SES) exist, but their determinants are not well understood.<h4>Objective</h4>This study investigates whether health conditions and lifestyle-related risk factors explain the SES inequalities in dementia risk.<h4>Methods</h4>6,346 participants from the English Longitudinal Study of Ageing were followed up from 2008/2009 until 2014/2015. We used Cox regression adjusted for age, gender, wealth/education, an ...[more]

PMID: 31424404

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Dataset Information

Modifiable Risk Factors Explain Socioeconomic Inequalities in Dementia Risk: Evidence from a Population-Based Prospective Cohort Study.

Background

Objective

Methods

Results

Conclusion

Publications

Modifiable Risk Factors Explain Socioeconomic Inequalities in Dementia Risk: Evidence from a Population-Based Prospective Cohort Study.

Similar Datasets

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