Plasma High-Resolution Metabolomics Differentiates Adults with Normal Weight Obesity from Lean Individuals.

ABSTRACT: OBJECTIVE:This study explored underlying metabolism-related dysfunction by examining metabolomic profiles in adults categorized as lean, as having normal weight obesity (NWO), or as having overweight/obesity. METHODS:Participants (N?=?179) had fasting plasma analyzed by liquid chromatography and high-resolution mass spectrometry for high-resolution metabolomics. Body composition was assessed by dual-energy x-ray absorptiometry. NWO was defined as BMI??30% for women and >?23% for men. Differentiating metabolomic features were determined by using linear regression models and likelihood ratio tests with false discovery rate correction. Mummichog was used for pathway and network analyses. RESULTS:A total of 222 metabolites significantly differed between the groups at a false discovery rate of q?=?0.2. Linoleic acid, ?-alanine, histidine, and aspartate/asparagine metabolism pathways were significantly enriched (all P?

SUBMITTER: Bellissimo MP 

PROVIDER: S-EPMC6839782 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature