Plasma High-Resolution Metabolomics Differentiates Adults with Normal Weight Obesity from Lean Individuals.
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ABSTRACT:
SUBMITTER: Bellissimo MP
PROVIDER: S-EPMC6839782 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Plasma High-Resolution Metabolomics Differentiates Adults with Normal Weight Obesity from Lean Individuals.
Bellissimo Moriah P MP Cai Qingpo Q Ziegler Thomas R TR Liu Ken H KH Tran Phong H PH Vos Miriam B MB Martin Greg S GS Jones Dean P DP Yu Tianwei T Alvarez Jessica A JA
Obesity (Silver Spring, Md.) 20191101 11
<h4>Objective</h4>This study explored underlying metabolism-related dysfunction by examining metabolomic profiles in adults categorized as lean, as having normal weight obesity (NWO), or as having overweight/obesity.<h4>Methods</h4>Participants (N = 179) had fasting plasma analyzed by liquid chromatography and high-resolution mass spectrometry for high-resolution metabolomics. Body composition was assessed by dual-energy x-ray absorptiometry. NWO was defined as BMI < 25 and body fat > 30% for wo ...[more]
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