Ontology highlight
ABSTRACT:
SUBMITTER: Valenti D
PROVIDER: S-EPMC6839876 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Valenti Dario D Neves João Filipe JF Cantrelle François-Xavier FX Hristeva Stanimira S Lentini Santo Domenico D Obšil Tomáš T Hanoulle Xavier X Levy Laura M LM Tzalis Dimitrios D Landrieu Isabelle I Ottmann Christian C
MedChemComm 20190722 10
Protein-protein interactions (PPIs) are at the core of regulation mechanisms in biological systems and consequently became an attractive target for therapeutic intervention. PPIs involving the adapter protein 14-3-3 are representative examples given the broad range of partner proteins forming a complex with one of its seven human isoforms. Given the challenges represented by the nature of these interactions, fragment-based approaches offer a valid alternative for the development of PPI modulator ...[more]