Alternative splicing as a regulator of development and tissue identity.
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ABSTRACT:
SUBMITTER: Baralle FE
PROVIDER: S-EPMC6839889 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Alternative splicing as a regulator of development and tissue identity.
Baralle Francisco E FE Giudice Jimena J
Nature reviews. Molecular cell biology 20170510 7
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in ...[more]
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